Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo

Abstract

Objective: Sulforaphane (SFN) has been reported to regulate signalling pathways relevant to chronic diseases. Our study investigated the impact of sulforaphane treatment on signalling pathways in chondrocytes and whether sulforaphane could block cartilage destruction in osteoarthritis.

 

Methods: Gene expression, histone acetylation, transcription factors nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor kappaB (NF-κB) signalling were examined in vitro The bovine nasal cartilage explant model (BNC) and destabilisation of medial meniscus (DMM) murine model of osteoarthritis were used to assess chondroprotection at the tissue and whole animal level.

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