Conclusions: Progesterone had no effect on undisturbed sleep but restored normal sleep when sleep was disturbed (while currently available hypnotics tend to inhibit deep sleep), acting as a "physiologic" regulator rather than as a hypnotic drug. Use of progesterone might provide novel therapeutic strategies for the treatment of sleep disturbances, in particular in aging where sleep is fragmented and of lower quality.
Anne Caufriez, Rachel Leproult, Mireille L'Hermite-Bal√©riaux, Myriam Kerkhofs and Georges Copinschi
Laboratory of Physiology (A.C., M.L.-B., G.C.), Section of Endocrinology of the Centre Hospitalo-Universitaire Saint-Pierre (A.C.), and Sleep Laboratory, Centre Hospitalo-Universitaire de Charleroi, A. V√©sale Hospital (M.K.), Universit√© Libre de Bruxelles, B-1070 Brussels, Belgium; and
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