The fluctuation of nonfasting triglycerides and cholesterol over 15 years was similar. In both women and men, stepwise increasing levels of nonfasting triglycerides were associated with increased risk of ischemic stroke. Compared to women with triglycerides <1 mmol/liter, multivariate adjusted hazard ratios ranged from 1.2 (95% confidence interval [CI], 0.9‚Äì1.7) for triglyceride levels of 1.00‚Äì1.99 mmol/liter to 3.9 (95%CI, 1.3‚Äì11.1) for triglyceride levels ‚â•5 mmol/liter (trend: p < 0.001); corresponding hazard ratios in men ranged from 1.2 (95%CI, 0.8‚Äì1.7) to 2.3 (95%CI, 1.2‚Äì4.3) (p = 0.001). Increasing cholesterol levels were not associated with risk of ischemic stroke except in men with cholesterol levels ‚â•9.00 mmol/liter vs <5.00 mmol/liter, with a hazard ratio of 4.4 (95%CI, 1.9‚Äì10.6).
In women, stepwise increasing levels of nonfasting triglycerides were associated with increasing risk of ischemic stroke while increasing cholesterol levels were not. In men, these results were similar except that cholesterol ‚â•9.00 mmol/liter was associated with increased risk of ischemic stroke. ANN NEUROL, 2011